L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver
نویسندگان
چکیده
منابع مشابه
Ox liver glutamate dehydrogenase
1. The effect of pyridoxal 5'-phosphate on the activity of ox liver glutamate dehydrogenase towards different amino acid substrates was investigated. 2. Both alanine and glutamate activities decreased steadily in the presence of pyridoxal 5'phosphate. 3. The alanine/glutamate activity ratio increased as a function of inactivation by pyridoxal 5'-phosphate, indicating that glutamate activity is ...
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Glutamate dehydrogenase (NAD) activity was measured in liver and diaphragm mitochondria from 48 h fasted rats. Kinetic studies were performed with diaphragm enzyme and the effects of L-leu, ADP and L-ala on the K(1)m and V(1)max for NH(4)+, and α-ketoglutarate were evaluated. L-leucine increases by 2-8 fold the V(1)max for all three substrates with no significant changes in the K(1)m. ADP incre...
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Background and Aims: Diabetes is one of the most important endocrine disrupters and is associated with various hormones, including those that can lead to diabetes. Glucocorticoid use may lead to insulin resistance. Dexamethasone is one of these glucocorticoid compounds. Glutamate dehydrogenase plays a key role in the production of glutamate in the secretion of insulin. Based on these hormonal i...
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Glutamate dehydrogenase (EC 1.4.1.3) (GDH) was studied with a system in vifro of tadpole and frog liver cube suspensions. A rise in GDH activity was observed in liver from tadpoles immersed in thyroxine (2.6 X lo-* M) for 8 days. A small rise in enzyme activity was observed in vitro in liver cubes from premetamorphic tadpoles. In the presence of thyroxine (2.6 X lo-* M to 2.6 X lo-lo M) or trii...
متن کاملEffects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction
Introduction: The main propose of this study was to determine the effect of parathion on activity of glutamate dehydrogenase (GDH) as a key enzyme in second phase secretion of insulin and to determine serum glucose levels in rats. Methods: To conduct the study, 35 rats were randomly divided into five groups (n=7). The serum glucose level of each group was measured and the total average was ca...
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ژورنال
عنوان ژورنال: Animal Nutrition
سال: 2018
ISSN: 2405-6545
DOI: 10.1016/j.aninu.2017.12.002